> it's probably better to run a multi-threaded setup, than individual frontends.

I recommend against using multiple threads if at all possible and unless absolutely required.

Only for one reason: multithreaded c++ programs are notoriously hard to debug.

In addition, one has to face several classes of bugs absent in single-threaded applications:

a) which thread "owns" which object
b) locking of all shared data
c) huge overheads from locking at high data rates (a performance bug)
d) correct locking order, dead locks, live locks
e) incomprehensible core dumps and stack traces
f) race conditions

To control 2 power supplies, run 2 frontend programs, 1 per power supply.

To control 64 frontend cards, run 1 frontend with many threads: 64 (per device) + 1 (main thread) + 1 (RPC handler) + 1 
(watchdog) + 1 (common event generator/data transmitter) + 1 (odb/web page status update). You *will* bump into each 
and every one of the problems (a) to (f) above.

K.O.