Anothe idea which comes to my mind, we could make it kind of object oriented, like

typedef struct {
  int handle;
  int crate;
  int amod;
  int fifo_mode;
  ...
} MVME_INTERFACE;

main()
{
  MVME_INERFACE *vme;

  vme = mvme_init(); // allocated and fills MVME_INTERFACE structure

  mvme_set_crate(vme, crate_no);
  mvme_set_address_mode(vme, A24);
  ...

  mvme_read(vme, vme_address, dest_addr, num_bytes);
  mvme_exit(vme);    // frees memory allocated in mvme_init()
}

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This way we would only have one structure containing all required parameters, and get/set
functions for it, like the OO textbooks propose it. This would actually make it thread
save. The "vme" pointer from above still has to be passed around to subroutines, but a
single pointer is better than lots of handles.